Evo MUSART 2012 was the First International Conference and the 10th European event on Biologically Inspired Music, Sound, Art and Design. It Convened during April 11-13, 2012, in Malaga, Spain. The main goal of evoMUSART 2012 was to bring together researchers who use biologically inspired computer techniques for artistic tasks, providing the opportunity to promote, present, and discuss ongoing work in the area. EvoMUSART 2012 received 43 submissions from 24 different countries across four continrnts. The papers underwent a rigorous double-blind peer-review process, each being reviewed by at least three members of the international Program Committee composed of 78 members from 20 countries on four different continents. The selection process resulted in this volume, with 15 papers accepted for oral presentation (34,9% acceptance rate) and 5 for poster presentation (46,5% global acceptance rate for talks and posters combined). The wide range of topics in this volume reflects the current state of research in the field, including theory, generation, computer-aided creativity, computational creativity, automation, and others. //ir